Oxygen saturation targeting in extremely preterm infants—more progress needed

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Target ranges of oxygen saturation in extremely preterm infants.

BACKGROUND Previous studies have suggested that the incidence of retinopathy is lower in preterm infants with exposure to reduced levels of oxygenation than in those exposed to higher levels of oxygenation. However, it is unclear what range of oxygen saturation is appropriate to minimize retinopathy without increasing adverse outcomes. METHODS We performed a randomized trial with a 2-by-2 fac...

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Target Ranges of Oxygen Saturation in Extremely Preterm Infants

*The authors are listed in the Appendix. The affiliations of the authors and other investigators in the Surfactant, Positive Pressure, and Pulse Oximetry Randomized Trial (SUPPORT) Study Group of the Neonatal Research Network of the Eunice Kennedy Shriver National Institute of Child Health and Human Development are listed in the Appendix. Address reprint requests to Dr. Waldemar A. Carlo at the...

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Oxygen saturation targets in extremely premature neonates.

12 McLaws ML, Pantle AC, Fitzpatrick KR, Hughes CF. More than hand hygiene is needed to affect methicillin-resistant Staphylococcus aureus clinical indicator rates: Clean hands save lives, part IV. Med J Aust 2009;191 (8 Suppl):S26–S31. 13 Jain R, Kralovic SM, Evans ME, Ambrose M, Simbartl LA, Obrosky DS, et al. Veterans Affairs initiative to prevent methicillin-resistant Staphylococcus aureus ...

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Higher oxygen saturation targets did not improve growth and neurodevelopment in extremely preterm infants.

*Information provided by author. MAIN RESULTS Analysis was by intention to treat. The groups did not differ for growth outcomes or major developmental abnormalities (table), or worst retinopathy (p = 0.34). However, the higher target group had higher rates of dependence on supplemental oxygen at 36 weeks PA (table) and spent more days on oxygen (median 40 v 17.5 d, p,0.001) than those in the st...

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Oxygen saturation and outcomes in preterm infants.

BACKGROUND The clinically appropriate range for oxygen saturation in preterm infants is unknown. Previous studies have shown that infants had reduced rates of retinopathy of prematurity when lower targets of oxygen saturation were used. METHODS In three international randomized, controlled trials, we evaluated the effects of targeting an oxygen saturation of 85 to 89%, as compared with a rang...

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ژورنال

عنوان ژورنال: The Journal of Pediatrics

سال: 2019

ISSN: 0022-3476

DOI: 10.1016/j.jpeds.2018.10.056